Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Open access Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans, by Krause-Kyora et al., Nature Communications (2018)

Abstract:

Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval skeletons from Denmark that show lesions specific for lepromatous leprosy (LL). First, we test the remains for M. leprae DNA to confirm the infection status of the individuals and to assess the bacterial diversity. We assemble 10 complete M. leprae genomes that all differ from each other. Second,

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Fast life history as adaptive regional response to less hospitable and unstable Early Indo-Iranian territory

Another interesting paper, Life in the fast lane: Settled pastoralism in the Central Eurasian Steppe during the Middle Bronze Age, by Judd et al. (2017).

Abstract (emphasis mine):

We tested the hypothesis that the purported unstable climate in the South Urals region during the Middle Bronze Age (MBA) resulted in health instability and social stress as evidenced by skeletal response.The skeletal sample (n = 99) derived from Kamennyi Ambar 5 (KA-5), a MBA kurgan cemetery (2040-1730 cal. BCE, 2 sigma) associated with the Sintashta culture. Skeletal stress indicators assessed included cribra orbitalia, porotic hyperostosis, dental enamel hypoplasia, and tibia

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Decline of genetic diversity in ancient domestic stallions in Europe

Open access research article Decline of genetic diversity in ancient domestic stallions in Europe, by Wutke et al., Science (2018), 4(4):eaap9691.

Abstract (emphasis mine):

Present-day domestic horses are immensely diverse in their maternally inherited mitochondrial DNA, yet they show very little variation on their paternally inherited Y chromosome. Although it has recently been shown that Y chromosomal diversity in domestic horses was higher at least until the Iron Age, when and why this diversity disappeared remain controversial questions. We genotyped 16 recently discovered Y chromosomal single-nucleotide polymorphisms in 96 ancient Eurasian stallions spanning the early domestication stages (Copper and

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The origins of the Tumulus culture: Proto-Lusatian and potential Proto-Balto-Slavic origins

Interesting chapter The birth of a new world. Barrows, warriors, and metallurgists, by Przemyslaw Makarowicz. In: Urbańczyk P. (Ed.) THE PAST SOCIETIES. Polish lands from the first evidence of human presence to the Early Middle Ages, Warszawa 2017, vol. 3, U. Bugaj (Ed.) (2000 – 500 BC), Warszawa, pp. 127-186.

Some interesting excerpts from the introduction (emphasis mine):

In the 17th century BC the northern reaches of the Únětice culture oecumene experienced a structural crisis and a settlement hiatus; no such interruption in development occurred in the southern or western regions, or further west in the circle

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Iberia in the Copper and Early Bronze Age: Cultural, demographic, and environmental analysis

New paper (behind paywall), Cultural, Demographic and Environmental Dynamics of the Copper and Early Bronze Age in Iberia (3300–1500 BC): Towards an Interregional Multiproxy Comparison at the Time of the 4.2 ky BP Event, Blanco-González, Lillios, López-Sáez, et al. J World Prehist (2018).

Abstract (emphasis mine):

This paper presents the first comprehensive pan-Iberian overview of one of the major episodes of cultural change in later prehistoric Iberia, the Copper to Bronze Age transition (c. 2400–1900 BC), and assesses its relationship to the 4.2 ky BP climatic event. It synthesizes available cultural, demographic and palaeoenvironmental evidence by region between

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First Iberian R1b-DF27 sample, probably from incoming East Bell Beakers

I had some more time to read the paper by Valdiosera et al. (2018) and its supplementary material.

One of the main issues since the publication of Olalde et al. (2018) (and its hundreds of Bell Beaker samples) was the lack of a clear Y-DNA R1b-DF27 subclades among East Bell Beaker migrants, which left us wondering when the subclade entered the Iberian Peninsula, since it could have (theoretically) happened from the Chalcolithic to the Iron Age.

My prediction was that this lineage found today widespread among the Iberian population crossed the Pyrenees quite early, during the Chalcolithic, with … Read the rest “First Iberian R1b-DF27 sample, probably from incoming East Bell Beakers”

Iberian prehistoric migrations in Genomics from Neolithic, Chalcolithic, and Bronze Age

New open access paper Four millennia of Iberian biomolecular prehistory illustrate the impact of prehistoric migrations at the far end of Eurasia, by Valdiosera, Günther, Vera-Rodríguez, et al. PNAS (2018) published ahead of print.

Abstract (emphasis mine)

Population genomic studies of ancient human remains have shown how modern-day European population structure has been shaped by a number of prehistoric migrations. The Neolithization of Europe has been associated with large-scale migrations from Anatolia, which was followed by migrations of herders from the Pontic steppe at the onset of the Bronze Age. Southwestern Europe was one of the last parts of

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Ancient genomes document multiple waves of migration in south-east Asian prehistory

Open access preprint at bioRxiv Ancient genomes document multiple waves of migration in Southeast Asian prehistory, by Lipson, Cheronet, Mallick, et al. (2018).

Abstract (emphasis mine):

Southeast Asia is home to rich human genetic and linguistic diversity, but the details of past population movements in the region are not well known. Here, we report genome-wide ancient DNA data from thirteen Southeast Asian individuals spanning from the Neolithic period through the Iron Age (4100-1700 years ago). Early agriculturalists from Man Bac in Vietnam possessed a mixture of East Asian (southern Chinese farmer) and deeply diverged eastern Eurasian (hunter-gatherer) ancestry characteristic

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Demographic research of Neolithic, Chalcolithic, and Bronze Age Europe

I mentioned in the Indo-European demic diffusion model the need to assess absolute and relative population growth – as well as other demographic changes – to interpret genomic data from the different European regions studied.

One article I referred to was Demographic traces of technological innovation, social change and mobility: from 1 to 8 million Europeans (6000–2000 BCE), by Johannes Müller.

Excerpts (emphasis mine):

The neolithization of Northern and Northwestern Europe (probably with new forms of slash-and-burn agriculture; Feeser et al. 2012; Schier 2009) was also one of the causes for the population increase observed.

The introduction of

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