mtDNA, lactase persistence, and admixr for ADMIXTOOLS


The following are some recent developments and updates:

I. Ancient DNA Dataset version 2

I.1. Accurate mtDNA haplogroups

I was meaning to update the mtDNA part of the Ancient DNA Dataset, and finally found some time to review FTDNA and YFull nomenclature (including hyperlinks), as well as those SNP calls from published samples found in YFull’s MTree. So, if you are interested in studies of mtDNA phylogeography, I think the data is now accurate and much more useful.

Given the number of columns and the size of the files, I have decided to post shorter standard versions, by … Read the rest “mtDNA, lactase persistence, and admixr for ADMIXTOOLS”

On the Ukraine Eneolithic outlier I6561 from Alexandria


Over the past week or so, since the publication of new Corded Ware samples in Narasimhan, Patterson et al. (2019) and after finding out that the R1a-M417 star-like phylogeny may have started ca. 3000 BC, I have been ruminating the relevance of contradictory data about the Ukraine_Eneolithic_o sample from Alexandria, its potential wrong radiocarbon date, and its implications for the Indo-European question.

How many other similar ‘controversial’ samples are there which we haven’t even considered? And what mechanisms are in place to control that the case of Hajji_Firuz_CA I2327 is not repeated?

Ukraine Eneolithic outlier I6561

It was not … Read the rest “On the Ukraine Eneolithic outlier I6561 from Alexandria”

FADS1 and the timing of human adaptation to agriculture


Open access FADS1 and the timing of human adaptation to agriculture, by Sara Mathieson & Iain Mathieson, bioRxiv (2018).


Variation at the FADS1/FADS2 gene cluster is functionally associated with differences in lipid metabolism and is often hypothesized to reflect adaptation to an agricultural diet. Here, we test the evidence for this relationship using both modern and ancient DNA data. We document pre-out-of-Africa selection for both the derived and ancestral FADS1 alleles and show that almost all the inhabitants of Europe carried the ancestral allele until the derived allele was introduced approximately 8,500 years ago by Early Neolithic farming

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